Use of  Colorado Protocol to Treat Parvo in Dogs 

Use of  Colorado Protocol to Treat Parvo in Dogs 

Consideration of a Veterinarian-based Outpatient Protocol for Treatment of Canine Parvoviral Enteritis

Canine parvovirus is a highly infectious disease that can result in severe dehydration, hypoglycemia (e.g., low blood sugar), vomiting, bloody diarrhea, nausea, and death without treatment. While this disease is completely preventable with vaccination, it is often seen in dogs that are unvaccinated, who haven’t undergone a full puppy vaccine series, who’s mothers weren’t vaccinated, or high stress (e.g., transporting animal rescue dogs), etc.

Canine parvovirus (CPV) is a serious and potentially fatal viral illness that remains common in dogs, despite the availability and efficacy of vaccinations. Without treatment, parvoviral enteritis has a mortality rate in excess of 90%. Hospitalization and aggressive care can decrease mortality to 10-30%; however, this approach is often cost prohibitive. In this article, we will review an outpatient protocol for dogs with parvoviral enteritis.

There has been recent investigation into the efficacy and safety of providing outpatient care to patients whose owners cannot afford inpatient treatment. Venn et al. established a protocol for outpatient care at Colorado State University that demonstrated 80% survival in outpatients compared to 90% survival for inpatients.

Signs of parvovirus include:

• Drooling
• Not eating
• Vomiting
• Diarrhea
• Bloody diarrhea
• Lethargy
• Not moving
• Trembling
• Weakness
• Painful abdomen
• Bloated abdomen
• Foul smell
• Dehydration
• Death

Treatment includes the following:

• Fluid therapy (ideally intravenously or “IV”)
• Anti-vomiting medication (e.g., Cerenia/maropitant)
• Antibiotics
• Blood work monitoring
• Anti-diarrheal medications
• Nutritional support
• Supportive care (e.g., including temperature monitoring, thermoregulation, etc.)

Unfortunately, most dogs need to be hospitalized for 3-5 days, depending on how they respond to therapy. This can often be several thousands of Rupeed, especially if your puppy requires 24-hour care.

“Colorado protocol.” What is this?

This is an “outpatient” protocol for parvovirus. This is based on a recent veterinary scientific paper published out of Colorado State University (CSU) veterinary school called “Evaluation of an outpatient protocol in the treatment of canine parvoviral enteritis”; this paper was published in the journal of Veterinary Emergency Critical Care about an “outpatient” canine parvovirus treatment.

Does this exist and why aren’t more veterinarians offering this?

While this study stated that it was an assessment out an outpatient protocol for dogs with parvovirus, it was a modified one. The outpatient patients were still hospitalized in a 24-hour facility but treated with outpatient medications (e.g., they were not treated with IV fluids, but still hospitalized). These outpatient puppies did have 24-hour care, but have their IV catheter removed a few hours after they were initially stabilized on presentation. For this reason, it’s important that the details of the study results be interpreted carefully.

In this study, a total of 40 puppies were hospitalized, with 20 dogs being treated as in-hospital patients with IV fluids, IV antivomiting medication, antibiotics, syringe feedings, and supportive care. The other 20 puppies were treated as “outpatient” but were still hospitalized for monitoring in a cage. Again, these outpatients initially had IV catheters placed for IV fluid resuscitation and blood glucose/electrolyte stabilization first, and then had the IV catheter removed a few hours later (This was to mimic if they went home with a pet owner). Then, CSU began injections that a pet owner could potentially be taught to do at home. The “outpatient dogs” were still hospitalized for an average of 3.8 days prior to a a true outpatient therapy. In other words, dogs had to be stabilized first, rehydrated, and have their blood sugar and and electrolytes (salt balance) corrected first. They also had to be started on strong anti-vomiting medications (e.g., Cerenia/maropitant) first to make sure that the puppies could hold down food and water, and that their nausea was controlled well first. What does this “outpatient hospitalization” mean? If you’re a pet owner trying this protocol at home, you likely need to treat a sick parvo puppy for at least 3-5 days at home AFTER initial stabilization by your veterinarian!

In this study, both in-hospital and “modified outpatient” puppies received IV fluids, correction of blood sugar, and initial stabilization. Dogs were also treated with antibiotics (e.g., cefoxitin), anti-vomiting medication (e.g., maropitant), and supportive care. For those dogs that were then treated “outpatient” once stable, they received the following:

• Subcutaneous (SC) fluid (30 mL/kg q 6 h) (fluids under the skin)
• Maropitant (1 mg/kg SC q 24 h)
• Cefovecin (8 mg/kg SC once; this antibiotic lasts about 5-7 days in dogs as a one time injection)
• Syringe feeding canned Hills a/d food (1 ml/kg orally q 6 h)

Keep in mind that while the survival was good in both groups [90% (18/20) for the inpatient group compared to 80% (16/20) for the outpatient group], dogs need daily visits to the veterinarian to make sure they are still hydrated, doing well, and responding to outpatient therapy. And just in case I didn’t make myself clear with the bold italics above, critically ill dehydrated sick puppies must be hospitalized first initially to stabilize them before an outpatient protocol can be considered! My general philosophy is to recommend aggressive IV fluid stabilization for 12-24 hours and then try outpatient therapy thereafter at home if the patient is stable.

Personally, I would personally modify the CSU protocol to the following to require less “pokes” under the skin. I’d be much more aggressive with fluids because young puppies have a much higher fluid requirement (180 ml/kg/day). So personally I would do:

• Subcutaneous (SC) fluid (60 mL/kg q 8 h) (fluids under the skin)
• Maropitant (1 mg/kg SC q 24 h)
• Cefovecin (8 mg/kg SC once; this antibiotic lasts about 5-7 days in dogs as a one time injection)
• Syringe feeding canned Hills a/d food (1 ml/kg orally q 6 h)
• ONLY if the puppy doesn’t look nauseated (e.g., drooling)
• Metoclopramide (Reglan) (0.5-1 mg/kg orally every 6 hours, given 30 minutes prior to feeding)
• Daily visits to your veterinarian to recheck them
• Checking a temperature every 8 hours
• Nursing care (e.g., keeping the mouth and rectum clean, changing the puppy potty pads) every 6 hours

Most importantly, keep in mind that the ideal treatment truly is hospitalization with IV fluids for several days. That said, if you can’t afford this treatment, work with your veterinarian as best you can to provide care at home. I personally hate to see puppies die or euthanized for this treatable disease, but know that 1 out of every 5 puppies passes away from parvovirus, even with outpatient therapy. Do what you can to save them as long as they are not suffering or painful or uncomfortable at all!

Prevention
More importantly, make sure to prevent parvovirus! Vaccination is almost 100% effective in preventing puppies from getting parvovirus, but puppies must go through a full puppy series. If the mother was vaccinated prior to getting pregnant, she will pass on some maternity antibodies (protection) early in life, but these maternal antibodies drop by about 5-6 weeks. Hence, puppies need to be vaccinated starting around 6 weeks of age with one DHPP vaccine, with boosters every 3-4 weeks thereafter until 16-18 weeks of age (especially in high risk breeds like pit bulls, Rottweilers, Dobermans, Alaskan sled dogs, Labrador retrievers, etc.). Keep in mind that puppies are not fully protected against parvovirus until they have completed their full puppy SERIES – not just one vaccine!

Also, limit any doggie day cares, dog parks, etc. until your dog has had at least 3 vaccines – otherwise, there is risk of exposure! When in doubt, check with your veterinarian to help prevent this potentially deadly disease!

P.S. If your dog was diagnosed and treated for parvovirus, NO dog parks, walks outside of your property, etc. for at least 4-6 weeks. Please don’t spread this to other dogs! (You don’t want bad doggy Karma!)

 Stepwise Veterinarian-based Outpatient  “Colorado protocol.”  for Treatment of Canine Parvoviral Enteritis

Initial visit

• TPR, exam, blood work (ideally CBC/Chemistry, at minimum PCV/TS, BG, blood smear)
• Dogs exhibiting hypovolemic shock should have a peripheral IVC placed, followed by intravenous volume resuscitation with crystalloids at 15-45 mL/kg IV, with additional crystalloids or colloids at 2-5 mL/kg administered as needed.
• Stable patients may be provided fluid therapy at 40-60 mL/kg SQ.
• If low blood glucose is identified, bolus 25% dextrose 1-2 mL/kg IV, with recheck BW performed to confirm resolution of hypoglycemia.
• External warming during cardiovascular resuscitation as needed to maintain rectal temperature at 99 degrees.
• Once stabilization is reached based on adequate improvement in perfusion parameters (heart rate, pulse quality, CRT, mucous membrane color, temperature, and mentation), outpatient protocol can be initiated.
• Administer Medications:
  • Convenia 8 mg/kg SQ
  • Pyrantel pamoate 10 mg/kg PO
  • Cerenia 1 mg/kg SQ
  • Metoclopramide 0.5 mg/kg SQ
  • Famotidine 1 mg/kg SQ
  • If painful, Buprenorphine 0.01-0.02 mg/kg IM

Subsequent Visits (ideally Twice Daily):

• TPR, exam, PCV/TS, BG, blood smear
• Administer Medications:
  • Cerenia 1 mg/kg SQ q24 hr
  • Metoclopramide 0.5 mg/kg q12 hr
  • Famotidine 1 mg/kg SQ q24 hr or 0.5 mg/kg SQ q12 hr
  • If Pt vomiting >3 times since last visit, rescue antiemetic protocol: Ondansetron 0.5 mg/kg SQ, to be repeated as needed according to the vomiting criteria
  • If painful, Buprenorphine 0.01-0.02 mg/kg IM q12 hr
  • If BG < 80 mg/dL, supplement with 1-5 mL Karo syrup bucally, to be repeated q4-6 hr
  • If K+ < 3.4 mEq/L, supplement with 2 mmol/L(mEq)/4.5kg
  • oral potassium supplement q4-6 hr (Tumil-L potassium gluconate)
• Enteral nutrition: If no interest in commercial convalescence diet offered at 1 mL/kg every 6 hours, syringe feed 1-3 mL at a time onto the tongue and allow dog to swallow – if patient is no longer receptive to this or exhibiting worsening nausea, syringe feeding should be stopped until next scheduled feeding attempt owners can be taught to administer syringe feedings at home between scheduled appointments, unless concern arises regarding owner’s inability to perform procedure safely, patient’s risk of aspiration, or other contraindications
• Fluid therapy:40-60 mL/kg SQ q12 hr

ADDITIONAL TREATMENT OPTIONS:

Another treatment to consider which is easy to administer in an OP setting is fecal microbiota transplant (FMT), using 10 grams of feces from a healthy dog diluted in 10mL of saline and administered rectally using a red rubber catheter and deposited into the proximal portion of the rectum.

In a clinical trial of CPV positive dogs receiving either standard Parvovirus treatment (STD) vs standard treatment plus FMT, among survivors treatment with FMT was associated with faster resolution of diarrhea, shorter duration of hospitalization, and 36.4% mortality in the STD group compared to 21.2% in puppies treated with FMT. FMT can be repeated every 48 hours during a CPV dog’s treatment. Donor feces can be collected and frozen in 10g aliquots for future use, making this an easy addition to any parvovirus protocol.

Failure to respond to outpatient protocol should be evaluated daily, and recommendation of inpatient hospitalization or humane euthanasia should be considered as warranted. This may include:

• Development of stuporous or obtunded mentation.
• Decline in body condition,
• Hyperlactatemia >4 mmol/L.
• Fever of >104 degrees
• Uncontrolled hemorrhagic diarrhea
• Intractable emesis
• >10% dehydration or loss of >10% body weight for 2 consecutive appointments
• or other subjective criteria for decline.

Given the 75-83% success rates reported for outpatient protocols, this can provide a viable option for the right patients and dedicated owners. Clinicians should note the 20-25% mortality rate of dogs with parvoviral enteritis that receive outpatient care when discussing treatment options with owners who are financially unable to pursue hospitalization. Additionally, success of an OP protocol still requires diligent monitoring (TPR, body weight, dehydration status, nausea, pain, blood work parameters) and follow-up assessments by a veterinarian to ensure they are responding appropriately.

FAQ ON “Colorado Protocol” CAN BE DOWNLOADED FROM HERE

FAQ ON COLORADO PROTOCOLS FOR PARVO

DR. UDAY KUMAR,CANINE SPECIALIST,HAJIPUR

References:
Evaluation of an outpatient protocol in the treatment of canine parvoviral enteritis. Venn EC, Preisner K, Boscan PL, Twedt DC, Sullivan LA. J Vet Emerg Crit Care 2017;27(1):52-65.

https://www.pashudhanpraharee.com/control-management-of-parvovirus-infection-in-dogs/

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