Mixed Mammary gland tumour in bitch
Nisha Kohli, Mir Mudasir, Seema Agarwal,Anuradha Gupta and Shodhan KV
Department of Pathology, College of Veterinary and Animal Sciences
G B Pant University of Agri. & Tech.Pantnagar-263145 Uttarakhand
Email: nisha.kohli112@gmail.com
Abstract:
A ten year old female Bhutia dog was presented to the veterinary teaching hospital, College of Veterinary and animal Science, Pantnagar, GBPUA&T with a complaint of swelling in inguinal and abdominal mammary glands. On physical examination, the masses were hard, fibrosed, pedunculated, measuring 6 X 12 cm and 4 X 8 cm in diameter (inguinal and abdominal respectively). The bitch was operated under general anaesthesia and both outgrowths were successfully removed. On gross examination the growths were found to be oval in shape, nodular, brownish green in colour. On histopathological examination using haematoxylin and eosin staining method the growth was diagnosed as fibroadenocarcinoma.
Keyword:
Bhutia bitch, fibroadenocarcinoma
Intoductrion:
Mammary gland tumours are the most common neoplasm in the female dog. It is extremely common in intact bitches, and account for atleast 50% of all reported neoplasms. Pure bred dogs have been found to be more prone to mammary tumours. Tumours can be solitary or can be multiple (approx. 50% of cases). They can develop in any gland but 4th and 5th mammary glands are most commonly affected. Mixed tumours are one of the most common tumour types in the female canine mammary glands. These tumours exhibited a complex histological pattern because they comprise elements from the epithelium and the mesenchyme and have the capacity to undergo malignant transformation, thereby giving rise mainly to carcinomas and less frequently carcinosarcomas and sarcomas in mixed tumours (Misdorp et al., 1999; Cassali et al., 2011). The mixed type, either benign or malignant, is one of the most common mammary gland tumour in bitches (Gartner et al., 1999, Richards et al., 2001). The mixed tumours represent 50% to 66% of canine mammary neoplasias (Jabara, 1960). These tumours usually appear in animals 6 to 10 years old, most frequently in females, although they can also affect males (Jabara, 1960; Sittner, 1939; Cotchin, 1947). Mixed tumours are thought to occur independently from breed (Nieberle et al., 1933). However, Mulligan (1949) found high incidence in the breeds of Cocker Spaniel, Fox Terrier and Boston terrier. They more commonly affect the caudal inguinal, caudal abdominal and cranial abdominal glands. Carcinomas in mixed tumours represent 10% to 40% of the total number of diagnosed carcinomas (Cassali et al., 2009; Richards et al., 2001; Priester, 1979).
Material and Method:
A ten year old female Bhutia dog was presented to the veterinary teaching hospital, College of Veterinary and animal Science, Pantnagar, GBPUA&T with a complaint of swelling in inguinal and abdominal mammary glands. On physical examination, the masses were hard, fibrosed, pedunculated, measuring 6 X 12 cm and 4 X 8 cm in diameter (inguinal and abdominal respectively). The bitch was operated under general anaesthesia and both outgrowths were successfully removed. After surgical remo8val, the growth was cauterized with silver nitrate. On gross examination the growths were found to be oval in shape, nodular, brownish green in colour. The tumorous growth after removal was preserved in 10% formal saline solution for histhological examination using haematoxylin and eosin staining method.
Result and Discussion:
Microscopically, tumorous growth revealed extensive proliferation of epithilial cells of lining epithelium of acini and fibrous connective tissue surrounding the acini. The proliferative cells are seen as tightly packed masses that had hyperchromatic nuclei and prominent nucleoli with presence of numerous mitotic figures. The acini were separated by band of fibrous connective tissue. The tumour reported here was considered malignant because of presence of pleomorphism, mitotic figures and hyper chromatic nuclei in proliferating cells. On the basis of these lesions, the swelling was diagnosed as mixed mammary gland tumour or fibroadenocarcinoma.
References:
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