Clinical Applications of Surgical Adhesives and Sealants in Veterinary
Often the terms “adhesives” and “sealants” are used interchangeably although their intended uses and functions are completely different. An adhesive exhibits characteristics that allow for in situ polymerization to cause adherence of tissue-to-tissue, or tissue-to-non-tissue surfaces. In general, tissue adhesives are meant to hold two sides of tissues together and support wound healing until regenerated tissue has enough mechanical strength. Sealants, on the other hand, are used as a barrier to leaks of fluids, such as blood, urine, or air. For example, sealants may be used to patch a puncture in the lung. Moreover, sealant devices may be applied to tissue wounds as hemostatic agents to control bleeding. Surgical adhesives are used to re-approximate wounded tissues in a variety of surgical applications including closure of lacerations, vessel and intestine anastomoses, and gluing skin flap to intestines to eliminate fluid accumulation. The most important characteristics of a durable surgical adhesive are appropriate mechanical properties while not hindering the natural healing process. The surgical adhesive needs to possess both high bulk and adhesive strengths to hold two ends of tissue together. However, if the adhesive is too strong and brittle, it can crack and break apart before the tissues heal properly. The materials for surgical adhesive products that are currently available include cyanoacrylates, albumin and glutaraldehyde, poly(ethylene glycol) (PEG), polyurethane, and fibrin.
Surgical Adhesive for veterinary use.
Surgical Adhesive
This treatment applies to the following species:
Description
Surgical Adhesive contains purified n-butyl cyanoacrylate monomer, stabilizers, and a D&C certified dye that permits differentiation between the product and bodily fluids.
ACTION: Surgical Adhesive is a monomeric formulation that, upon contact with an alkaline, pH environment, polymerizes to form a thin, flexible waterproof bandage. It polymerizes in approximately one second after contact with moist wound surfaces. Polymerization is slower on a dry field. By sealing off capillary ends, Surgical Adhesive acts as a hemostatic agent. It also seals off exposed nerve endings. Epithelial regeneration begins to occur under the Surgical Adhesive bandage in 3-4 days. The bandage is sloughed naturally in 5-7 days.
Surgical Adhesive Indications
Surgical Adhesive is indicated for veterinary use only. The liquid form is indicated for wound management in a variety of situations such as:
- Lacerations and abrasions
- Cat declaws
- Cuts
- Tail docking
Contraindications
Surgical Adhesive is contraindicated in the management of infected and deep puncture wounds.
Directions For Use
Proper preparation of the wound site is critical for using Surgical Adhesive successfully. If antiseptic treatment is desired for the wound site, wash the area with a povidone solution. Do not use other topical ointments or salves because they may interfere with the formation of the Surgical Adhesive bandage.
After preparing the wound site, use sterile gauze to remove any accumulating blood or moisture from the wound. DO NOT APPLY VETONE SURGICAL ADHESIVE OVER A POOL OF BLOOD OR FLUID. This causes improper polymerization of the bandage and results in premature sloughing of the bandage.
Hold the tip of the bottle, fitted with the applicator tip, slightly above the wound. Release the Surgical Adhesive drops, one at a time, until the wound is completely covered. The Surgical Adhesive bandage should extend slightly beyond the wound onto healthy tissue. DO NOT OVER-APPLY. A light, thin coat is better than a thick, heavy coat. Too much Surgical Adhesive will lose flexibility and could develop microscopic cracks.
USE OF THE APPLICATOR TIP: The applicator tip fits snugly into the tip on the bottle. This tip allows greater control over the size and placement of the drop. Also, the tip can be bent, providing easier delivery in tight places. After use, remove the pipette and discard. Wipe the applicator tip clean before replacing the cap.
REMOVAL: Surgical Adhesive can be removed from skin or other surfaces with dimethylsulfoxide or acetone.
PRECAUTIONS/WARNINGS:
- Avoid contact with skin and eyes.
- Avoid contact with clothing because the stain will be permanent.
- Avoid contact with metal instruments.
Storage
Store at room temperature. Avoid prolonged exposure to temperatures above 32°C (90°F). The product should not be used beyond the indicated expiration date.
How Supplied
Supplied in individual packages. Each package contains:
- Dropper bottle containing 2.0 mL
- Applicator tips
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